| Species |
Mouse |
| Protein Construction |
Nectin-4 (Gly31-Ser347)
Accession # Q8R007 |
His |
| N-term |
C-term |
|
| Purity |
> 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Biological Activity |
Immobilized Nectin-4, His, Mouse (Cat.No.: Z03826) at 2 μg/ml on the plate can bind Human Nectin-1, hFc Tag. |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
35.4 kDa |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4. |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Nectin-4 is a tumor-associated antigen. It is probably involved in cell adhesion through trans-homophilic and -heterophilic interactions. Nectin-4 is overexpressed in urothelial carcinoma and several other malignancies. It is a promising target for antibody-drug conjugates (ADCs). |
| Synonyms |
EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
