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Safety and Efficacy of Intravenous and Intrathecal Delivery of AAV9-Mediated ARSA in Minipigs

Authors: Aysilu Mullagulova , Alisa Shaimardanova , Valeriya Solovyeva , Yana Mukhamedshina , Daria Chulpanova , Alexander Kostennikov, Shaza Issa, Albert Rizvanov

Journal: Int J Mol Sci .

PubMed ID: 37298156

Doi: 10.3390/ijms24119204

Products & Services: Gene Synthesis

KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing

Authors: Ashutosh P Dubey, Brianna L Tylec, Amartya Mishra, Katherine Sortino, Runpu Chen, Yijun Sun, Laurie K Read

Journal: Nucleic Acids Research

PubMed ID: 37140035

Doi: doi.org/10.1093/nar/gkad292

Products & Services: Gene Synthesis

Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex

Authors: Mandy S M Wan, Reyhan Muhammad, Marios G Koliopoulos, Theodoros I Roumeliotis, Jyoti S Choudhary, Claudio Alfieri

Journal: nature communications

PubMed ID: 37137925

Doi: 10.1038/s41467-023-38276-0

Products & Services: Gene Synthesis

Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex

Authors: Cassandra K Hayne, Kevin John U Butay, Zachary D Stewart, Juno M Krahn, Lalith Perera, Jason G Williams, Robert M Petrovitch, Leesa J Deterding, A Gregory Matera, Mario J Borgnia, Robin E Stanley

Journal: Nat Struct Mol Biol

PubMed ID: 37231153

Doi: 10.1038/s41594-023-00991-z

Products & Services: Gene Synthesis

Engineered ketocarotenoid biosynthesis in the polyextremophilic red microalga Cyanidioschyzon merolae 10D

Authors: Mark Seger , Fakhriyya Mammadova , Melany Villegas-Valencia , Barbara ´ Bastos de Freitas , Clarissa Chang , Iona Isachsen , Haley Hemstreet , Fatimah Abualsaud , Malia Boring , Peter J. Lammers , Kyle J. Lauersen

Journal: Metabolic Engineering Communications

Doi: 10.1016/j.mec.2023.e00226

Products & Services: Gene Synthesis

MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity

Authors: Damodar Gullipalli, Takashi Miwa, Madhu Golla, Sayaka Sato, Sree Angampalli, Wen-Chao Song

Journal: J Immunol

PubMed ID: 36988282

Doi: 10.4049/jimmunol.2200932

Products & Services: Gene Synthesis

BcMYB111 Responds to BcCBF2 and Induces Flavonol Biosynthesis to Enhance Tolerance under Cold Stress in Non-Heading Chinese Cabbage

Authors: Xiaoshan Chen , Ying Wu , Zhanghong Yu , Zhanyuan Gao , Qiang Ding , Sayyed Hamad Ahmad Shah , Wenyuan Lin , Ying Li , Xilin Hou

Journal: Int J Mol Sci .

PubMed ID: 37240015

Doi: 10.3390/ijms24108670

Products & Services: Gene Synthesis

In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g

Authors: Irina S. Abaeva, Yani Arhab, Anna Miscicka, Christopher U.T. Hellen, and Tatyana V. Pestova

Journal: bioRxiv .

PubMed ID: 37292671

Doi: 10.1101/gad.350829.123

Products & Services: Gene Synthesis

A highly efficient transgene knock-in technology in clinically relevant cell types

Authors: Alexander G Allen, Samia Q Khan, Carrie M Margulies, Ramya Viswanathan, Swarali Lele, Laura Blaha, Sean N Scott, Kaitlyn M Izzo, Alexandra Gerew, Rithu Pattali, Nadire R Cochran, Carl S Holland, Amy H Zhao, Stephen E Sherman, Michael C Jaskolka, Meng Wu, Aaron C Wilson, Xiaoqi Sun, Dawn M Ciulla, Deric Zhang, Jacqueline D Nelson, Peisheng Zhang, Patrizia Mazzucato, Yan Huang, Georgia Giannoukos, Eugenio Marco, Michael Nehil, John A Follit, Kai-Hsin Chang, Mark S Shearman, Christopher J Wilson, John A Zuris

Journal: Nat Biotechnol

PubMed ID: 37127662

Doi: 10.1038/s41587-023-01779-8

Products & Services: Gene Synthesis

Deep learning models to predict the editing efficiencies and outcomes of diverse base editors

Authors: Nahye Kim, Sungchul Choi, Sungjae Kim, Myungjae Song, Jung Hwa Seo, Seonwoo Min, Jinman Park, Sung-Rae Cho, Hyongbum Henry Kim

Journal: Nat Biotechnol

PubMed ID: 37188916

Doi: 10.1038/s41587-023-01792-x

Products & Services: Gene Synthesis