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Optogenetic inhibition of Gα signalling alters and regulates circuit functionality and early circuit formation

Authors: Jayde Lockyer, Andrew Reading, Silvia Vicenzi, Caroline Delandre, Owen Marshall, Robert Gasperini, Lisa Foa, John Y Lin

Journal: biorxiv

PubMed ID: 37214843

Doi: 10.1101/2023.05.06.539674

Products & Services: Proteins, Expression, Isolation and Analysis

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Authors: Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai-Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang

Journal: Sci Adv

PubMed ID: 37205756

Doi: 10.1126/sciadv.adf8698

Products & Services: Molecular Biology Reagents

Analysis and comparisons of gene expression changes in patient- derived neurons from ROHHAD, CCHS, and PWS

Authors: A Kaitlyn Victor, Tayler Hedgecock, Martin Donaldson, Daniel Johnson, Casey M Rand, Debra E Weese-Mayer, Lawrence T Reiter

Journal: Front Pediatr

PubMed ID: 37234859

Doi: 10.3389/fped.2023.1090084

Products & Services: Molecular Biology Reagents

Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa

Authors: Xingyun Wang, Cong Liu, Nino Rcheulishvili, Dimitri Papukashvili, Fengfei Xie, Jiao Zhao, Xing Hu, Kaiwei Yu, Nuo Yang, Xuehua Pan, Xueyan Liu, Peng George Wang, Yunjiao He

Journal: npj Vaccines

PubMed ID: 37231060

Doi: 10.1038/s41541-023-00672-4

Products & Services: Polyclonal Antibody Services

Inositol pyrophosphates activate the vacuolar transport chaperone complex in yeast by disrupting a homotypic SPX domain interaction

Authors: Joka Pipercevic, Bastian Kohl, Ruta Gerasimaite, Véronique Comte-Miserez, Sarah Hostachy, Thomas Müntener, Elia Agustoni, Henning Jacob Jessen, Dorothea Fiedler, Andreas Mayer, Sebastian Hiller

Journal: Nat Commun

PubMed ID: 37156835

Doi: 10.1038/s41467-023-38315-w

Products & Services: Molecular Biology Reagents

Electronegative clusters modulate folding status and RNA binding of unstructured RNA-binding proteins

Authors: Steve Zaharias, Talia Fargason, Rory Greer, Yuhua Song, Jun Zhang

Journal: Protein Sci

PubMed ID: 37060324

Doi: 10.1002/pro.4643

Products & Services: Gene Synthesis

Deficient Immune Response following SARS-CoV-2 Vaccination in Patients with Hepatobiliary Carcinoma: A Forgotten, Vulnerable Group of Patients

Authors: Malte B Monin, Leona I Baier, Jens G Gorny, Moritz Berger, Taotao Zhou, Robert Mahn, Farsaneh Sadeghlar, Christian Möhring, Christoph Boesecke, Kathrin van Bremen, Jürgen K Rockstroh, Christian P Strassburg, Anna-Maria Eis-Hübinger, Matthias Schmid, Maria A Gonzalez-Carmona

Journal: Liver Cancer

PubMed ID: 37901199

Doi: 10.1159/000529608

Products & Services: Molecular Biology Reagents

De Novo Computational Design of a Lipase with Hydrolysis Activity towards Middle-Chained Fatty Acid Esters

Authors: Jinsha Huang, Xiaoman Xie, Zhen Zheng, Luona Ye, Pengbo Wang, Li Xu, Ying Wu, Jinyong Yan, Min Yang, Yunjun Yan

Journal: Int J Mol Sci

PubMed ID: 37239928

Doi: 10.3390/ijms24108581

Products & Services: Gene Synthesis

PTPMT1 protects cardiomyocytes from necroptosis induced by γ-ray irradiation through alleviating mitochondria injury

Authors: Jing Yi, Liang Yue, Yuning Zhang, Ning Tao, Han Duan, Lin Lv, Yingxia Tan, Hua Wang

Journal: Am J Physiol Cell Physiol

PubMed ID: 37154493

Doi: 10.1152/ajpcell.00466.2022

Products & Services: Codon Optimization

The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells

Authors: David L Bauer, Louay Bachnak, Vanessa M Limbert, Rebecca M Horowitz, Robin L Baudier, Shaina J D'Souza, Victoria E Immethun, Jonathan R Kurtz, Samuel B Grant, James B McLachlan

Journal: J Immunol

PubMed ID: 37023458

Doi: 10.4049/jimmunol.2200221

Products & Services: Peptide Synthesis