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ToxinSensor Chromogenic LAL Endotoxin Assay Kit> | ... Bacterial endotoxins were removed using the Toxineraser endotoxin removal kit (GenScript, Piscata way, NJ) according to manufacturer's instruction 16 . The level of endotoxin was determined using ToxinSensor TM Chromogenic LAL Endotoxin Assay Kit (GenScript). ... | Get A Quote |
A single amyloidogenic protein is implicated in multiple neurological diseases and capable of generating a number of aggregate "strains" with distinct structures. Among the amyloidogenic proteins, α-synuclein generates multiple patterns of proteinopathies in a group of diseases, such as Parkinson disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). However, the link between specific conformations and distinct pathologies, the key concept of the strain hypothesis, remains elusive. Here we show that in the presence of bacterial endotoxin, lipopolysaccharide (LPS), α-synuclein generated a self-renewable, structurally distinct fibril strain that consistently induced specific patterns ... More