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Controlled Release of Second Generation mTOR Inhibitors to Restrain Inflammation in Primary Immune Cells

AAPS J.. 2017-07; 
Gosselin EA, Tostanoski LH, Jewell CM
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Peptide Synthesis Transgenic T Cell Proliferation. To measure T cell proliferation specific to the self-antigen myelin oligodendrocyte glycoprotein (MOG) peptide (MEVGWYRSPFSRVVHLYRNGK, Genscript), a DC/T cell co-culture was used... Get A Quote

摘要

Autoimmune disease occurs when the immune system incorrectly targets the body's own tissue. Inflammatory CD4+ T cell phenotypes, such as TH1 and TH17, are key drivers of this attack. Recent studies demonstrate treatment with rapamycin-a key inhibitor of the mTOR pathway-can skew T cell development, moving T cell responses away from inflammatory phenotypes and toward regulatory T cells (TREGS). TREGS are important in inducing and maintaining tolerance to self-antigens, creating new potential to treat autoimmune diseases more effectively and specifically. Next generation analogs of rapamycin, such as everolimus and temsirolimus, confer increased potency with reduced toxicity, but are understudied in the context o... More

关键词

controlled release; immune tolerance and autoimmunity; microparticle and nanoparticle; rapamycin, everolimus, and temsirolimus; vaccine and immunotherapy
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