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Protein Tyrosine Phosphatase-N13 (PTPN13) Promotes Myofibroblast Resistance to Apoptosis in Idiopathic Pulmonary Fibrosis.

Am. J. Respir. Crit. Care Med.. 2018;

BambergAlison，RedenteElizabeth F，GroshongSteve D，TuderRubin M，CoolCarlyne D，KeithRebecca C，EdelmanBenjamin L，BlackBart P，CosgroveGregory P，WynesMurry W，Curran-EverettDouglas，De LangheStijn，OrtizLuis A，ThorburnAndrew，RichesDavid

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Peptide Synthesis	Acylated peptides were synthesized by Genscript (Piscataway, NJ).Next, biotinylated octapeptides were synthesized (Genscript, Piscataway, NJ) comprising the last 8 residues of authentic human Fas (RNEIQSLV) and a control Fas mutant nonPTPN13-interacting peptide (RNEIQSVL).	Get A Quote

摘要

Idiopathic pulmonary fibrosis (IPF) is a progressive， fibrotic interstitial lung disease characterized by (myo)fibroblast accumulation and collagen deposition. Resistance to Fas-induced apoptosis is thought to facilitate (myo)fibroblast persistence in fibrotic lung tissues， by poorly understood mechanisms.