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Immune Cross-Opsonization Within emm Clusters Following Group A Streptococcus Skin Infection: Broadening the Scope of Type-Specific Immunity.

Clin. Infect. Dis.. 2017;

FrostHannah R，LahoDelphine，Sanderson-SmithMartina L，LicciardiPaul，DonathSusan，CurtisNigel，KadoJoseph，DaleJames B，SteerAndrew C，SmeestersPier

Products/Services Used	Details	Operation
Peptide Synthesis	Synthetic peptides of the N-terminal 50 amino acids of M proteins were obtained commercially (GenScript, Piscataway, New Jersey) from sequences based on a representative collection of 1086 M proteins and were used to coat assay plates [11].	Get A Quote

摘要

Group A Streptococcus (GAS) skin infections are particularly prevalent in developing nations. The GAS M protein， by which strains are differentiated into >220 different emm types， is immunogenic and elicits protective antibodies. A major obstacle for vaccine development has been the traditional understanding that immunity following infection is restricted to a single emm type. However， recent evidence has led to the hypothesis of immune cross-reactivity between emm types.