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Discovery of a novel oocyte-specific Krüppel-associated box domain-containing zinc finger protein required for early embryogenesis in cattle.

Mech. Dev.. 2017; 
HandJacqelyn M,ZhangKun,WangLei,KogantiPrasanthi P,MastrantoniKristen,RajputSandeep K,AshryMohamed,SmithGeorge W,YaoJi
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Polyclonal Antibody Services … method. Differences of P < 0.05 were considered significant. 2.5. Generation of anti-ZNFO antibody and western blot analysis. The ZNFO antibody was prepared commercially by GenScript Corporation (Piscataway, NJ). Polyclonal … Get A Quote

摘要

Zinc finger (ZNF) transcription factors interact with DNA through zinc finger motifs and play important roles in a variety of cellular functions including cell growth, proliferation, development, apoptosis, and intracellular signal transduction. One-third of ZNF proteins in metazoans contain a highly conserved N-terminal motif known as the Krüppel-associated box (KRAB) domain, which acts as a potent, DNA-binding dependent transcriptional repression module. Analysis of RNA-Seq data generated from a bovine oocyte cDNA library identified a novel transcript, which encodes a KRAB-containing ZNF transcription factor (named ZNFO). Characterization of ZNFO mRNA expression revealed that it is exclusively ... More

关键词

Cattle,Embryogenesis,KRAB domain,Oocyte,Zinc fi
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