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Neuroglobin as key mediator in the 17β-estradiol-induced antioxidant cell response to oxidative stress

Antioxid Redox Signal. 2020; 
Solar Fernandez V, Cipolletti M, Ascenzi P, Marino M, Fiocchetti M.
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Gene Synthesis … CRISP/Cas9 gene editing The biallelic NGB K/O of NGB gene NGB/KO (K/O) MCF-7 clone and its NC were developed by GenScript Corporation (Piscataway, NJ) applying the CRISP/Cas9 system on WT MCF-7 Cell culture … Get A Quote

摘要

Aims: Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. In breast cancer cells, we recently identified the monomeric heme-globin neuroglobin (NGB) as part of a new mechanism induced by the steroid hormone 17β-estradiol (E2) against oxidative stress. While there is mounting evidence suggesting a critical role of NGB as a sensor of oxidative stress, scarce information is available about its involvement in NRF-2 pathway activation in breast cancer cells. Results: Although NGB is not involved in the rapid E2-induced NRF-2 stability, E2 loses the capacity to regulate the expres... More

关键词

breast cancer; estradiol; neuroglobin; oxidative stress; stress response
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