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Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.

Oncotarget. 2017; 
Bilger A, Plowshay J,, Ma S,, Nawandar D,, Barlow EA, Romero-Masters JC, Bristol JA, Li Z, Tsai MH, Delecluse HJ, Kenney SC,.
Products/Services Used Details Operation
Polyclonal Antibody Services The following primary anti-human antibodies were used: anti-EBNA2 (mouse, #90543, clone PE2, Abcam, 1:500); anti-LMP1 (mouse, #78113, clones CS1-4, Abcam, 1:500); anti-EBNA3A (sheep polyclonal, Abcam, 1:2000); anti-EBNA3c (sheep polyclonal, Exalpha Pharmaceuticals, 1:2000); anti-β- actin (mouse, A5441, clone AC-15, Sigma, 1:5,000); anti- NFkB2p100/p52 (rabbit, #3017, Cell Signaling, 1:1000); anti-phosphoNFkBp65 (ser536, rabbit, #3303, clone 93H1, Cell Signaling 1:1000); anti-cMYC (rabbit, #32072, clone Y69, Abcam, 1:10,000); anti-Cyclin E (mouse, #sc-247, clone HE12, Santa Cruz, 1:250); anti-PARP (rabbit, #9542, Cell Signaling, 1:1000); anti-p53 (mouse, clone DO-1, Santa Cruz, 1:1000); anti-BZLF1 (mouse, sc-53904, BZ1, Santa Cruz, 1:500); anti-BMRF1 (mouse, MAB8186, clone R3, Millipore, 1:3,000); anti- EBV p18 protein (goat polyclonal; Thermo Fisher Scientific, 1:2000); and anti- glyceraldehyde-3-phosphate dehydrogenase (GAPDH)- horseradish peroxidase (HRP) antibody (A00192; Genscript; 1:4,000). Get A Quote

摘要

EBV infection causes mononucleosis and is associated with specific subsets of B cell lymphomas. Immunosuppressed patients such as organ transplant recipients are particularly susceptible to EBV-induced lymphoproliferative disease (LPD), which can be fatal. Leflunomide (a drug used to treat rheumatoid arthritis) and its active metabolite teriflunomide (used to treat multiple sclerosis) inhibit de novo pyrimidine synthesis by targeting the cellular dihydroorotate dehydrogenase, thereby decreasing T cell proliferation. Leflunomide also inhibits the replication of cytomegalovirus and BK virus via both "on target" and "off target" mechanisms and is increasingly used to treat these viruses in organ transplant recipie... More

关键词

FDA-approved; humanized mouse model; lymphoma; lymphoproliferative disease; therapy
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