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Enhancement of peri-implant bone formation via parathyroid hormone administration in a rat model at risk for medication-related osteonecrosis of the jaw

J Periodontal Implant Sci. 2020-03; 
Ji Young Park, Hyun A Heo, Suhyun Park, Sung Woon Pyo
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Proteins, Expression, Isolation and Analysis … The OVX-ZP group (n=10) contained ovariectomized rats that were administered zoledronate (Sigma-Aldrich, St. Louis, MO, USA) and PTH (rhPTH 1-34; GenScript, Piscataway, NJ, USA) using vehicle (0.1 M Tris-HCl, pH 7.5, and 2% rat serum albumin) … Get A Quote

摘要

Dental implant-associated medication-related osteonecrosis of the jaw has been frequently reported in patients administered bisphosphonates (BPs) to prevent osteoporosis. The aim of this study was to investigate the effect of intermittent administration of parathyroid hormone (PTH) on peri-implant bone in the maxillae of ovariectomized rats systemically administered BPs.

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