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A cytoskeletal protein complex is essential for division of intracellular amastigotes of

J Biol Chem. 2020; 
Felice D Kelly, Khoa D Tran, Jess Hatfield, Kat Schmidt, Marco A Sanchez, Scott M Landfear
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摘要

Previous studies in have identified the cytoskeletal protein KHARON as being important for both flagellar trafficking of the glucose transporter GT1 and for successful cytokinesis and survival of infectious amastigote forms inside mammalian macrophages. KHARON is located in three distinct regions of the cytoskeleton: the base of the flagellum, the subpellicular microtubules, and the mitotic spindle. To deconvolve the different functions for KHARON, we have identified two partner proteins, KHAP1 and KHAP2, which associate with KHARON. KHAP1 is located only in the subpellicular microtubules, whereas KHAP2 is located at the subpellicular microtubules and the base of the flagellum. Both and null mutants are unab... More

关键词

Leishmania, cytokinesis, cytoskeleton, flagellum, infectious disease, protein complex, protein targeting
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