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Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin

J Pept Sci. 2021-12; 
Kabuzi R Mbuayama, Helena Taute, Adam A Strӧmstedt, Megan J Bester, Anabella R M Gaspar
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Peptide Synthesis … 20, 21 This broad spectrum of activity along with their low toxicity towards … The purity (GenScript >95%; LifeTein 95%) and molecular mass of the peptides were … using reverse-phase high-performance liquid chromatography (HPLC) and mass spectrometry, respectively … Get A Quote

摘要

Candida albicans is the principal opportunistic fungal pathogen in nosocomial settings and resistance to antifungal drugs is on the rise. Antimicrobial peptides from natural sources are promising novel therapeutics against C. albicans. OsDef2 defensin was previously found to be active against only Gram-positive bacteria, whereas derived fragments Os and its cysteine-free analogue, Os-C, are active against Gram-positive and Gram-negative bacteria at low micromolar concentrations. In this study, OsDef2-derived analogues and fragments were screened for anticandidal activity with the aim to identify peptides with antifungal activity and in so doing obtain a better understanding of the structural requirements for a... More

关键词

antimicrobial peptides, defensins, membrane permeabilization, reactive oxygen species, tick
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