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RNA-binding protein YBX1 promotes cell proliferation and invasiveness of nasopharyngeal carcinoma cells binding to AURKA mRNA

J Cancer. 2021-04; 
Yuanyuan Ban, Yixin Tan, Xiaoling Li, Xiayu Li, Zhaoyang Zeng, Wei Xiong, Guiyuan Li, Bo Xiang, Mei Yi
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Recombinant Proteins … Cell lysate was centrifuged at 13,000 g for 15 min at 4 °C. The supernatant was collected and pre-precipitated with 20μL of recombinant protein A/G agarose (GenScript, Nanjing, China) for 1 h at 4 °C to remove non-specific binding, then the supernatant was precipitated with … Get A Quote

摘要

RNA-binding proteins (RBPs) play essential roles in post-transcriptional control of gene expression. Dysregulation of RBPs is intensively implicated in development and progression of human diseases, including cancers. However, the roles of RBPs in nasopharyngeal carcinoma (NPC), which is a distinct subtype of head and neck cancer, remain elusive. NPC-related RBPs were explored by analyzing GEO database and high-throughput proteomic data obtained from crosslinking immunoprecipitation. The expression levels of Y box binding protein 1 (YBX1) protein in NPC samples were measured by immunohistochemistry (IHC) staining. The association of YBX1 protein levels with prognosis of NPC patients was analyzed by Kaplan-Meie... More

关键词

AURKA, RNA binding protein, YBX1, posttranscriptional regulation, translation.
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