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A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19

Front Immunol. 2021-05; 
Joo Guan Yeo, Jing Yao Leong, Shi Huan Tay, Karen Donceras Nadua, Danielle E Anderson, Amanda Jin Mei Lim, Xiang Wen Ng, Su Li Poh, Dianyan Guo, Katherine Nay Yaung, Pavanish Kumar, Martin Wasser, Sharifah Nur Hazirah, Nursyuhadah Sutamam, Camillus Jian Hui Chua, Martin Qui, Randy Foo, Akshamal Mihiranga Gamage, Kee Thai Yeo, Lakshmi Ramakrishna, Thaschawee Arkachaisri, Barnaby E Young, David Chien Lye, Lin-Fa Wang, Chia Yin Chong, Natalie Woon Hui Tan, Jiahui Li, Kai-Qian Kam, Florent Ginhoux, Koh Cheng Thoon, Jerry Kok Yen Chan, Chee Fu Yung, Salvatore Albani
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Catalog Antibody … 2 spike glycoprotein were synthesized to identify T cell subsets critical to protective immunity ( Supplemental Table 4 ) (GenScript, USA … 2 spike protein S1 RBD-specific IgG was quantified using a commercial ELISA kit (Catalog #: MBS398005, MyBioSource Inc., USA) according … Get A Quote

摘要

An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ memory CD4 T cells and virus-specific follicular helper T (T) cells. Overall, these findings pinpoint cri... More

关键词

COVID-19, SARS-CoV-2, follicular helper T cells, mass cytometry, regulatory T cells
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