Products/Services Used | Details | Operation |
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Catalog Antibody> | … 2 spike glycoprotein were synthesized to identify T cell subsets critical to protective immunity ( Supplemental Table 4 ) (GenScript, USA … 2 spike protein S1 RBD-specific IgG was quantified using a commercial ELISA kit (Catalog #: MBS398005, MyBioSource Inc., USA) according … | Get A Quote |
An accurate depiction of the convalescent COVID-19 immunome will help delineate the immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized the immune architecture in patients recovering from mild COVID-19. We identified a virus-specific immune rheostat composed of an effector T (T) cell recall response that is balanced by the enrichment of a highly specialized regulatory T (T) cell subset. Both components were reactive against a peptide pool covering the receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein. We also observed expansion of IFNγ memory CD4 T cells and virus-specific follicular helper T (T) cells. Overall, these findings pinpoint cri... More