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Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

NPJ Vaccines . . 2024-02; 
Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang
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Gene Synthesis The plasmid-bearing VSV antigenome lacking VSV-G ORF but with an additional GFP ORF was synthesized at GenScript (Nanjing, China). Get A Quote

摘要

Hantaan virus (HTNV) is a pathogenic orthohantavirus prevalent in East Asia that is known to cause hemorrhagic fever with severe renal syndrome (HFRS), which has a high fatality rate. However, a Food and Drug Administration (FDA)-approved vaccine is not currently available against this virus. Although inactivated vaccines have been certified and used in endemic regions for decades, the neutralizing antibody (NAb) titer induced by inactivated vaccines is low and the immunization schedule is complicated, requiring at least three injections spanning approximately 6 months to 1 year. Replication-competent vesicular stomatitis virus (VSV)-based vaccines provide prolonged protection after a single injection. In this ... More

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