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Dissecting components of the gene cluster under iron limitation

Microbiol Spectr. 2023-12; 
Tomas Richardson-Sanchez, Anson C K Chan, Brendil Sabatino, Helen Lin, Erin C Gaynor, Michael E P Murphy
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Gene Synthesis … genes within the cluster and to provide insight into the essentiality of each functional unit for iron acquisition, this study used a genetic approach to test individual fet gene … (Genscript Get A Quote

摘要

is a bacterium that is prevalent in the ceca of farmed poultry such as chickens. Consumption of ill-prepared poultry is thus the most common route by which infects the human gut to cause a typically self-limiting but severe gastrointestinal illness that can be fatal to very young, old, or immunocompromised people. The lack of a vaccine and an increasing resistance to current antibiotics highlight a need to better understand the mechanisms that make a successful human pathogen. This study focused on the functional components of one such mechanism-a molecular system that helps thrive despite the restriction on growth-available iron by the human body, which typically defends against pathogens. In providing a de... More

关键词

Campylobacter jejuni, Fet system genes, X-ray crystallography, iron transport, thiol-disulfide oxidoreductase
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