ToxinEraser™ Endotoxin Removal Resin

The ToxinEraser™ Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.

产品编号	L00402
规格	1 ml Resin (Total 2 ml) 大单询价
数量
价格	￥500


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Description

Lipopolysaccharide (LPS) is a bacterial endotoxin, and a major constituent of the cell walls of gram-negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is the principal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, and fatal shock in mammalian hosts. The removal of these endotoxins is highly necessary for downstream processes.

The ToxinEraser^™ Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.

产品概述

Product Information

Binding Capacity	Up to 2,000,000 EU/ml resin.
Ligand	Modified PMB (Polymixin B)
pH Stability	pH 5 -10
Support Matrix	4% cross-linked agarose, spherical beads
Mean Particle Size	90 μm
Types of substances that can be applied to the column	Protein, including peptides and antibody, polysaccharide, etc.
Applicable Ionic Strength	0.1 to 0.5 M NaCl
Substances tested that do not interfere with performance	20% DMSO, 20% ethanol, 20% glycerol; 1 M urea, 300 mM imidazole; 0.05% Tween 20, 10 mM DTT, etc.