CHO-K1/SCTR/Gα15 Stable Cell Line
The secretin receptor SCTR is Gs-coupled GPCRs expressed in the duodenum, jejunum, pancreas, tertiary bronchus, lung parenchyma and pulmonary artery. There appears to be important species differences in the cellular and organ distribution of secretin and secretin family receptors. The best example of this is the confusing series of observations in pancreas of guinea-pig, rat, and human. There are also differences in the pharmacologic profile of secretin receptors from different species, despite minimal changes in primary structure.
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