Figure BCA-1 induced concentration-dependent stimulation of intracellular calcium mobilization in CHO-K1/Gα15/CXCR5 cells. The cells were loaded with Calcium-4 prior to being stimulated with agonist BCA-1 (GenScript, Cat No.: Z02826). The intracellular calcium change was normalized and measured by FLIPR. The relative fluorescent units (RFU) were normalized and plotted against the log of the cumulative doses of BCA-1 (Mean ± SD, n = 2). The EC50 of BCA on this cell was 0.11 µM.
CHO-K1/Gα15/CXCR5
Chemokine (C-X-C motif) receptor 5 (CXCR5) belongs to the CXC chemokine receptor family. CXCR5 plays crucial roles in B-cells migration into B-cell follicles of spleen and Peyer patches. CXCR5 reduces maintenance of immature neural cell populations and enhances proliferation of subgranular zone cells in the hippocampal dentate gyrus. GenScript’s human CCR1-expressing stable subline is guaranteed to function properly in the calcium flux assay.
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