CHO-K1/CTLA4 Stable Cell Line

CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans.

产品编号	M00530
规格	2 vials 大单询价
数量
价格	询价


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Description

CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.

The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans.

Synonyms

ALPS5; CD; CD152; CELIAC3; GRD4; GSE; IDDM12

产品概述

Applications

Binding assay or use as immunogen.

产品简介

Storage	Liquid nitrogen immediately upon receiving
Species	Human
Stability	15 passages

培养条件

Freeze Medium	95% complete growth medium, 5% (V/V) DMSO (Cat. #D2650, Sigma)
Culture Medium	F-12K (Kaighn’s), 10% FBS, 8 μg/ml Puromycin (Cat. #A11138-03, Gibco)