Figure 1. FACS analysis of B7-H4 expression in CHO-K1/B7-H4 cells.
CHO-K1/B7-H4 Stable Cell Line
B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers.
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