ED50 < 0.02 ng/ml, measured in a cell proliferation assay using NFS-60 cells.
Lane 1: 3 μg of G-CSF, Mouse, non-reducing (NR)
Lane 2: 3 μg of G-CSF, Mouse, reducing (R)
> 95% as analyzed by SDS-PAGE
G-CSF, Mouse
Granulocyte Colony-Stimulating Factor (G-CSF), also known as CSF-3 and MGI-1G, is a cytokine and hormone belonging to the IL-6 superfamily. It is expressed by monocytes, macrophages, endothelial cells, fibroblasts and bone marrow stroma. G-CSF stimulates the bone marrow to produce granulocytes and stem cells, and specifically stimulates the proliferation and differentiation of the neutrophilic granulocyte lineage. G-CSF has been used to stimulate white blood cell production after chemotherapy. It has also been used to boost the number of hematopoietic stem cells after bone marrow transplantation.
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