Immobilized Human CD40, His Tag at 0.5 μg/ml (100 μl/Well). Dose response curve for Human CD40L, hFc Tag with the EC50 of 0.22 μg/ml determined by ELISA.
Human CD40 on SDS-PAGE under reducing conditions. The purity is greater than 95%.
The purity of Human CD40 is greater than 95% as determined by SEC-HPLC.
Immobilized Human CD40, His Tag at 0.5 μg/ml (100 μl/Well). Dose response curve for Human CD40L, hFc Tag with the EC50 of 0.22 μg/ml determined by ELISA.
Human CD40 on SDS-PAGE under reducing conditions. The purity is greater than 95%.
The purity of Human CD40 is greater than 95% as determined by SEC-HPLC.
CD40, His, Human
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
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