The ED50 as determined by a cell proliferation assay using BALB/c 3T3 cells is 5.42 ng/ml.
Lane 1: 2 μg of PDGF-BB, Human, non-reducing (N)
Lane 2: 2 μg of PDGF-BB, Human, reducing (R)
≥ 98% as analyzed by SDS-PAGE
PDGF-BB, Human
Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).
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¥872 | |
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