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Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

Products & Services: Proteins, Expression, Isolation and Analysis

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Authors: Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S Fahad, Sheila N Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T Yin, Tongqing Zhou, David D Ho, Peter D Kwong, Brandon J DeKosky

Journal: Front Immunol

PubMed ID: 36119018

Doi: 10.3389/fimmu.2022.977064

Products & Services: Proteins, Expression, Isolation and Analysis

A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques

Authors: Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen

Journal: Front Plant Sci

PubMed ID: 36247553

Doi: 10.3389/fpls.2022.901978

Products & Services: Proteins, Expression, Isolation and Analysis

A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies

Authors: Meiniang Wang, Likun Wei, Haitao Xiang, Bingzhao Ren, Xiaopan Liu, Lin Jiang, Naibo Yang, Jiahai Shi

Journal: Anal Biochem

PubMed ID: 36108795

Doi: 10.1016/j.ab.2022.114871

Products & Services: Proteins, Expression, Isolation and Analysis

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

Authors: Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic

Journal: Elife

PubMed ID: 36155655

Doi: 10.7554/eLife.82766

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy

Authors: Qi Yu , Xuanyunjing Gong , Yue Tong , Min Wang , Kai Duan , Xinyu Zhang , Feng Ge , Xilan Yu , Shanshan Li

Journal: NaCommunt

PubMed ID: 36167807

Doi: 10.1038/s41467-022-33423-5

Products & Services: Proteins, Expression, Isolation and Analysis

SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

Products & Services: Proteins, Expression, Isolation and Analysis

A 1-aminocyclopropane-1-carboxylic-acid (ACC) dipeptide elicits ethylene responses through ACC-oxidase mediated substrate promiscuity

Authors: John Vaughan-Hirsch, Dongdong Li, Albert Roig Martinez, Stijn Roden, Jolien Pattyn, Shu Taira, Hitomi Shikano, Yoko Miyama, Yukari Okano, Arnout Voet, Bram Van de Poel

Journal: Front Plant Sci

PubMed ID: 36172554

Doi: 10.3389/fpls.2022.995073

Products & Services: Proteins, Expression, Isolation and Analysis

Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma

Authors: Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-Yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-Lok Cheng

Journal: Mol Ther

PubMed ID: 36146933

Doi: 10.1016/j.ymthe.2022.09.012

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay

Authors: Liping Zhou, Tingting Liu, Mengxia Mo, Yulong Shi, Leyun Wu, Yishui Li, Qiuping Qin, Weiliang Zhu, Chengkun Wu, Likun Gong, Zhijian Xu

Journal: J Chem Inf Model

PubMed ID: 36053674

Doi: 10.1021/acs.jcim.2c00881

Products & Services: Proteins, Expression, Isolation and Analysis