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Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models

Authors: Debashis Dutta, Malabendu Jana, Ramesh Kumar Paidi, Moumita Majumder, Sumita Raha, Sridevi Dasarathy, Kalipada Pahan

Journal: J Clin Invest

PubMed ID: 37552543

Doi: 10.1172/JCI161987

Products & Services: Proteins, Expression, Isolation and Analysis

A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo

Authors: Burcu Bestas, Sandra Wimberger, Dmitrii Degtev, Alexandra Madsen, Antje K Rottner, Fredrik Karlsson, Sergey Naumenko, Megan Callahan, Julia Liz Touza, Margherita Francescatto, Carl Ivar Möller, Lukas Badertscher, Songyuan Li, Silvia Cerboni, Niklas Selfjord, Elke Ericson, Euan Gordon, Mike Firth, Krzysztof Chylinski, Amir Taheri-Ghahfarokhi, Mohammad Bohlooly-Y, Mike Snowden, Menelaos Pangalos, Barrett Nuttall, Pinar Akcakaya, Grzegorz Sienski, Marcello Maresca

Journal: Nat Commun

PubMed ID: 37673883

Doi: 10.1038/s41467-023-41240-7

Products & Services: Proteins, Expression, Isolation and Analysis

Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Authors: David Flores-Solis, Irina P Lushpinskaia, Anton A Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M Pietrek, Patrick Cramer, Lukas S Stelzl, Bojan Zagrovic, Markus Zweckstetter

Journal: Nat Commun

PubMed ID: 37749095

Doi: 10.1038/s41467-023-41633-8

Products & Services: Proteins, Expression, Isolation and Analysis

One-step production of fully biotinylated and glycosylated human Fc gamma receptors

Authors: Minhyo Kang, Zening Wang, Xin Ge

Journal: Biotechnol Prog

PubMed ID: 37734055

Doi: 10.1002/btpr.3392

Products & Services: Proteins, Expression, Isolation and Analysis

Oligomeric State of β-Coronavirus Non-Structural Protein 10 Stimulators Studied by Small Angle X-ray Scattering

Authors: Wolfgang Knecht, S Zoë Fisher, Jiaqi Lou, Céleste Sele, Shumeng Ma, Anna Andersson Rasmussen, Nikos Pinotsis, Frank Kozielski

Journal: Int J Mol Sci

PubMed ID: 37686452

Doi: 10.3390/ijms241713649

Products & Services: Nucleic Acid Purification & Analysis

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Authors: Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 37689716

Doi: 10.1038/s41467-023-41191-z

Products & Services: Peptide Synthesis

CST2 is activated by RUNX1 and promotes pancreatic cancer progression by activating PI3K/AKT pathway

Authors: Rongwen Ou, Chengjie Lin, Youting Chen

Journal: Arch Biochem Biophys

PubMed ID: 37722526

Doi: 10.1016/j.abb.2023.109760

Products & Services: Custom RNAi Services

Isofagomine inhibits multiple TcdB variants and protects mice from induced mortality

Authors: Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm

Journal: biorxiv

PubMed ID: 37781587

Doi: 10.1101/2023.09.19.558375

Products & Services: Combinatorial DNA Libraries

A temperature dependent pilin promoter for production of thermostable enzymes in Thermus thermophilus

Authors: Lennart Kirchner, Volker Müller, Beate Averhoff

Journal: Microb Cell Fact

PubMed ID: 37726752

Doi: 10.1186/s12934-023-02192-1

Products & Services: Codon Optimization

Prime editor-mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS-CoV-2 variants

Authors: Wenwen Zhao， Jifang Li, Xiao Wang， Wei Xu， Bao-Qing Gao， Jiangchao Xiang， Yaofeng Hou, Wei Liu, Jing Wu, Qilian Qi, Jia Wei, Xiaoyu Yang, Lu Lu,Li Yang, Jia Chen, Bei Yang

Journal: MedComm.

Doi: 10.1002/mco2.356

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis