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A culture method with berbamine, a plant alkaloid, enhances CAR-T cell efficacy through modulating cellular metabolism

Authors: Shin-Ichiro Takayanagi, Sayaka Chuganji, Masahiro Tanaka, Bo Wang, Saki Hasegawa, Ken Fukumoto, Nariaki Wasano, Makoto Kakitani, Nakaba Ochiai, Yohei Kawai, Tatsuki Ueda, Akihiro Ishikawa, Yuko Kurimoto, Asami Fukui, Sanae Kamibayashi, Eri Imai, Atsushi Kunisato, Hajime Nozawa, Shin Kaneko

Journal: Commun Biol

PubMed ID: 38834758

Doi: 10.1038/s42003-024-06297-0

Products & Services: Proteins, Expression, Isolation and Analysis

The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation

Authors: Gerard J Chu, Charles G Bailey, Rajini Nagarajah, Sharon M Sagnella, Stephen Adelstein, John E J Rasko

Journal: Cancer Cell Int

PubMed ID: 38105188

Doi: 10.1186/s12935-023-03171-7

Products & Services: Proteins, Expression, Isolation and Analysis

An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity

Authors: Carbonneau S, Sharma S, Peng L, Rajan V, Hainzl D, Henault M, Yang C, Hale J, Shulok J, Tallarico J, Porter J, Brogdon JL, Dranoff G, Bradner JE, Hild M, Guimaraes CP

Journal: Cell chemical biology

PubMed ID: 33333026

Doi: 10.1016/j.chembiol.2020.11.012

Products & Services: Gene Synthesis

Augmenting the Effectiveness of CAR-T Cells by Enhanced Self-Delivery of PD-1-Neutralizing scFv

Authors: Yu Ping, Feng Li, Shufeng Nan, Daiqun Zhang, Xiaojuan Shi, Jiqi Shan, Yi Zhang

Journal: Front Cell Dev Biol

PubMed ID: 32974346

Doi: 10.3389/fcell.2020.00803

Products & Services: Proteins, Expression, Isolation and Analysis

Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma

Authors: Cui J, Wang H, Medina R, Zhang Q, Xu C, Indig IH, Zhou J, Song Q, Dmitriev P, Sun MY, Guo L, Wang Y, Rosenblum JS, Kovach JS, Gilbert MR, Zhuang Z,

Journal: Cancers (Basel)

PubMed ID: 31935881

Doi: 10.3390/cancers12010139

Products & Services: Recombinant Proteins

First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach

Authors: Teilo H Schaller, David J Snyder, Ivan Spasojevic, Patrick C Gedeon, Luis Sanchez-Perez, John H Sampson

Journal: J Immunother Cancer

PubMed ID: 32273346

Doi: 10.1136/jitc-2019-000213

Products & Services: Molecular Biology Reagents

Analysis of in vitro activity of PSCA-specific CARs in the context of human NK cell line YT

Authors: Daria A. Matvienko , Sergey V. Kulemzin, Anna S. Smagina, Tatyana N. Belovezhets, Anton N. Chikaev, Olga Y. Volkova, Nikolay A. Chikaev, Olga A. Koval, Elena V. Kuligin, Alexandr V. Taranin, Andrey A. Gorchakov

Journal: Cellular Therapy and Transplantation (CTT).

Doi: 10.18620/ctt-1866-8836-2018-7-2-70-77

Products & Services: Catalog Antibody

Analysis of in vitro activity of PSCA-specific CARs in the context of human NK cell line YT.

Authors: Daria A, Matvienko, Sergey V. Kulemzin, Anna S. Smagina, Tatyana N. Belovezhets, Anton N. Chikaev, Olga Y. Volkova, Nikolay A. Chikaev, Olga A. Koval, Elena V. Kuligina, Alexandr V. Taranin, Andrey A. Gorchakov.

Journal: Cellular Therapy and Transplantation

Products & Services: Catalog Antibody

IL-12 conditioning improves retrovirally mediated transduction efficiency of CD8+ T cells.

Authors: Andrijauskaite K, Suriano S, Cloud CA, Li M, Kesarwani P, Stefanik LS, Moxley KM, Salem ML, Garrett-Mayer E, Paulos CM, Mehrotra S, Kochenderfer JN, Cole DJ, Rubinstein MP.

Journal: Cancer Gene Ther. 22(7):360-7

PubMed ID: 26182912

Products & Services: Catalog Antibody