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JNK regulates FoxO-dependent autophagy in neurons.

Genes Dev.. 2011-02;

Ping Xu, Madhumita Das, Judith Reilly, and Roger J. Davis. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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Bioinformatics Tools	...NEN). Immunoblot analysis of immunoprecipitates was performed using the One-Step Complete Immunoprecipitation-Western kit (Genscript Corp.). Protein kinase assays CDK2 activity was measured in an in vitro kinase assay using Rb-C fusion protein (Cell Signaling...	Get A Quote

摘要

The cJun N-terminal kinase (JNK) signal transduction pathway is implicated in the regulation of neuronal function. JNK is encoded by three genes that play partially redundant roles. Here we report the creation of mice with targeted ablation of all three Jnk genes in neurons. Compound JNK-deficient neurons are dependent on autophagy for survival. This autophagic response is caused by FoxO-induced expression of Bnip3 that displaces the autophagic effector Beclin-1 from inactive Bcl-XL complexes. These data identify JNK as a potent negative regulator of FoxO-dependent autophagy in neurons.