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A Model for Dimerization of the SOX Group E Transcription Factor Family.

PLoS One.. 2016-08;  11(8):e0161432
Ramsook SN, Ni J, Shahangian S, Vakiloroayaei A, Khan N, Kwan JJ, Donaldson LW. Department of Biology, York University, Toronto, ON, Canada.
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摘要

Group E members of the SOX transcription factor family include SOX8, SOX9, and SOX10. Preceding the high mobility group (HMG) domain in each of these proteins is a thirty-eight amino acid region that supports the formation of dimers on promoters containing tandemly inverted sites. The purpose of this study was to obtain new structural insights into how the dimerization region functions with the HMG domain. From a mutagenic scan of the dimerization region, the most essential amino acids of the dimerization region were clustered on the hydrophobic face of a single, predicted amphipathic helix. Consistent with our hypothesis that the dimerization region directly contacts the HMG domain, a peptide corresponding to ... More

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