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Enhanced disease reduction using clozapine, an atypical antipsychotic agent, and glatiramer acetate combination therapy in experimental autoimmune encephalomyelitis.

Mult Scler J Exp Transl Clin.. 2017-03; 
Green LK,Zareie P,Templeton N,Keyzers RA,Connor B,La Flamme AC5
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Peptide Synthesis ...50mg/mouse myelin oligodendro- cyte glycoprotein (MOG)35 55 peptide (Genscript, Piscataway, NJ, USA) emulsified in Freund’s Adjuvant … Get A Quote

摘要

BACKGROUND: Atypical antipsychotic agents (AAP) alleviate the symptoms of severe mental health disorders, such as schizophrenia, by antagonizing dopamine and serotonin receptors. Recently, AAP have also been shown to exhibit immunomodulatory properties in the central nervous system (CNS). OBJECTIVE: Building on research which demonstrated the ability of the AAP risperidone and clozapine to modify the disease course of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), we aimed to more fully investigate the potential of clozapine as a possible treatment for MS. RESULTS: We report that orally administered clozapine significantly reduced the disease severity of EAE in a... More

关键词

Experimental autoimmune encephalomyelitis; atypical antipsychotic agents; clozapine; glatiramer acetate; immune modulation; multiple sclerosis
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