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The enhanced antitumor-specific immune response with mannose- and CpG-ODN-coated liposomes delivering TRP2 peptide.

Theranostics. 2018; 
LaiChunhui，DuanSiliang，YeFang，HouXiaoqiong，LiXi，ZhaoJin，YuXia，HuZixi，TangZhuoran，MoFengzhen，YangXiaomei，LuXiao
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Peptide Synthesis … HS) at the 3′ end for lipid linking. The H-2K b -restricted peptides Mut1 52-59 (FEQNTAQP) and TRP2 180-188 (SVYDFFVWL) were synthesized by Genscript (Nanjing, China). Antibodies used in this study include: anti-CD11b … Get A Quote

摘要

Dendritic cell (DC)-based cancer vaccines is a newly emerging and potent form of immune therapy. As for any new technology， there are still considerable challenges that need to be addressed. Here， we investigate the antitumor potential of a novel liposomal vaccine， M/CpG-ODN-TRP2-Lipo.

关键词

dendritic cells-based cancer vaccine，immunotherapy，liposome，tumor，tumor antigen-specific CD8+ T-c
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