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Effects of TNF receptor blockade on in vitro cell survival and response to negative energy balance in dairy cattle.

J Anim Sci Biotechnol. 2018;

MartelC A，MamedovaL K，MintonJ E，GarciaM，LegalletC，Bradfor

Products/Services Used	Details	Operation
Recombinant Proteins	… After 24 h of TRLP administration, cows were challenged with recombinant bovine TNFα at 5 μg/kg BW as an intravenous bolus [19]. Recombinant bovine TNFα was custom-produced in an E. coli expression system (Genscript Corp., Piscataway, NJ) as previously described [3] …	Get A Quote
Bacterial Expression System		Get A Quote

摘要

Associative data and some controlled studies suggest that the inflammatory cytokine tumor necrosis factor (TNF) α can induce fatty liver in dairy cattle. However， research demonstrating that TNFα is a necessary component in the etiology of bovine fatty liver is lacking. The aim of this work was to evaluate whether blocking TNFα signaling with a synthetic cyclic peptide (TNF receptor loop peptide; TRLP) would improve liver metabolic function and reduce triglyceride accumulation during feed restriction.