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Introduction of F446I mutation in the K13 propeller gene leads to increased ring survival rates in Plasmodium falciparum isolates.

Malar. J.. 2018-07;

WangJing，HuangYufu，ZhaoYuemeng，YeRun，ZhangDongmei，PanWei

Products/Services Used	Details	Operation
Peptide Synthesis	… Antibody and western blot. The antibody against k13 protein was produced by GenScript Corporation (USA). Briefly, a synthetic peptide (MEGEKVKTKANSISC) was conjugated with keyhole limpet haemocyanin and formulated with adjuvant …	Get A Quote

摘要

Mutations in the Plasmodium falciparum k13 gene are associated with artemisinin (ART) resistance. However， it is unclear whether the F446I mutation， the most prevalent allele at the China-Myanmar border and north of Myanmar， is associated with ART resistance. Therefore， the aim of this study was to investigate the role of this mutation in ART resistance by generating transgenic parasites expressing the F446I mutant allele.