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Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain.

J Neuroinflammation. 2018-02;

HernandesMarina S，LassègueBernard，HilenskiLula L，AdamsJonathan，GaoNing，KuanChia-Yi，SunYu-Yo，ChengLihong，KikuchiDaniel S，YepesManuel，GriendlingKat

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Proteins, Expression, Isolation and Analysis	… Following separation by SDS-PAGE, proteins were transferred to a nitrocellulose membrane and assessed by western blotting with primary antibodies against Poldip2 (ab181841; Abcam or custom made by GenScript Corporation, Piscataway, NJ), IκBα (ab32518; Abcam), β …	Get A Quote

摘要

Polymerase δ-interacting protein 2 (Poldip2) is a multifunctional protein that regulates vascular extracellular matrix composition and matrix metalloproteinase (MMP) activity. The blood-brain barrier (BBB) is a dynamic system assembled by endothelial cells， basal lamina， and perivascular astrocytes， raising the possibility that Poldip2 may be involved in maintaining its structure. We investigated the role of Poldip2 in the late BBB permeability induced by cerebral ischemia.