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Egg White Ovotransferrin-Derived ACE Inhibitory Peptide Ameliorates Angiotensin II-Stimulated Insulin Resistance in Skeletal Muscle Cells.

Mol Nutr Food Res. 2018-01;

SonMyoungjin，ChanCatherine B，WuJian

Products/Services Used	Details	Operation
Peptide Synthesis	… Dihydroethidium (DHE) and Hoechst 33342 were purchased from Thermo Fisher Scientific (Thermo Fisher Scientific, Burlington, Canada). The tripeptide IRW, IQW, and LKP were synthesized by Genscript (Piscataway, NJ, USA) …	Get A Quote

摘要

The renin-angiotensin system (RAS) is a major contributor to the development of insulin resistance and its related complications. Egg white ovotransferrin-derived tripeptides， IRW (Ile-Arg-Trp)， IQW (Ile-Gln-Trp)， or LKP (Leu-Lys-Pro) are previously identified as the inhibitors of angiotensin-converting enzyme (ACE)， a key enzyme in the RAS. This study aims at determining whether these peptides are effective in improving insulin resistance， and their mechanisms of action， in a rat derived skeletal muscle cell line (L6 cells).