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Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice.

Open Virol J. 2018; 
GallayPhilippe A，ChatterjiUdayan，KirchhoffAaron，GandarillaAngel，PylesRichard B，BaumMarc M，MossJo
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Peptide Synthesis … and Use Committee. 2.2. Vaginal and Rectal HIV Infection Studies in Humanized BLT Mice. The parent and modified C5A peptides were obtained from GenScript, and their amino acid sequences are given in Fig. (​1A1A) and … Get A Quote

摘要

In the absence of a vaccine， there is an urgent need for the identification of effective agents that prevent HIV transmission in uninfected individuals. Non-vaccine Biomedical Prevention (nBP) methods， such as topical or systemic pre-exposure prophylaxis (PrEP)， are promising strategies to slow down the spread of AIDS.

关键词

Bone marrow/Liver/Thymus Mice， C5A， Microbicide， Rectal challenge， Vaginal challenge，HIV transmis
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