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Immunological characterization of Plasmodium vivax Pv32， a novel predicted GPI-anchored merozoite surface protein

Malar. J.. 2018-07;

ChengYang, WangBo, LuFeng, HanJin-Hee, AhmedMd Atique, HanEun-

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Codon Optimization	… 36. Plasmid constructs. To generate the SLI knockin constructs, codon-adjusted and linker-flanked 2×FKBP (synthesized by Genscript) was ligated into pARL-GFP 37 to obtain pARL-2×FKBP-GFP. All linkers had previously been used with these domains.	Get A Quote

摘要

The development of an effective malarial vaccine is an urgent need. Most glycosylphosphatidylinositol (GPI)-anchored proteins of Plasmodium parasites are exposed to neutralizing antibodies， and several are advanced vaccine candidates. In the present study， Plasmodium vivax Pv32 (PVX_084815) as a hypothetical， predicted GPI-anchored and cysteine-rich motif was identified from our previous findings with a focus on its antigenic profiling. The orthologue gene pv32， a predicted GPI anchor of P. falciparum PF3D7_1434400， has still not been well studied.