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Coagulation factor XI vaccination: an alternative strategy to prevent thrombosis

J. Thromb. Haemost.. 2017-01; 
ZhongC, ZhangL, ChenL, DengL
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Recombinant Proteins … chromatography. Proteins were further purified with a Superdex G75 column (GE Healthcare, Piscataway, NJ, USA). The purified proteins were analyzed on 4–20% ExpressPlus PAGE gels (GenScript, Nanjing, China). Animals. Male … Get A Quote

摘要

Essentials Coagulation Factor (F) XI is a safe target for the development of antithrombotics. We designed an antigen comprising the human FXI catalytic domain and diphtheria toxin T domain. Antigen immunization reduced plasma FXI activity by 54% and prevented thrombosis in mice. FXI vaccination can serve as an effective strategy for thrombosis prevention.

关键词

antithrombotic，diphtheria toxin，factor XI，inflammation，vac
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