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Milk fat globule-epidermal growth factor-factor VIII-derived peptide MSP68 is a cytoskeletal immunomodulator of neutrophils that inhibits Rac1

J. Surg. Res.. 2017-02;

HendricksLouie, AzizMonowar, YangWeng-Lang, NicastroJeffrey, CoppaGene F, SymonsMarc, Wang

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Peptide Synthesis	… 19 Briefly, MSP68 is a pentapeptide prepared from human MFG-E8 protein sequences, which contained an RGD motif flanked by valine residues on both sides (GenScript, Piscataway, NJ). Isolation and purification of bone marrow–derived neutrophils …	Get A Quote

摘要

Prolonged neutrophil infiltration leads to exaggerated inflammation and tissue damage during sepsis. Neutrophil migration requires rearrangement of their cytoskeleton. Milk fat globule-epidermal growth factor-factor VIII-derived short peptide 68 (MSP68) has recently been shown to be beneficial in sepsis-induced tissue injury and mortality. We hypothesize that MSP68 inhibits neutrophil migration by modulating small GTPase Rac1-dependent cytoskeletal rearrangements.