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In vitro characterization of SynthoPlate™ (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice

J. Thromb. Haemost.. 2017-02; 
ShuklaM, SekhonU D S, BetapudiV, LiW, HickmanD A, PawlowskiC L, DyerM R, NealM D, McCraeK R, Sen Gu
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Peptide Synthesis … The peptides TRYLRIHPQSWVHQI (VBP), [GPO] 7 (CBP), and cyclo-CNPRGDY(OEt)RC (FMP) were custom-synthesized from Genscript (Piscataway, NJ USA) conjugated to DSPE-PEG 2000 -COOH and characterized by mass spectrometry (Fig S.2). Phosphate-buffered saline … Get A Quote

摘要

Essentials Platelet transfusion suffers from availability， portability， contamination， and short shelf-life. SynthoPlate™ (synthetic platelet technology) can resolve platelet transfusion limitations. SynthoPlate™ does not activate resting platelets or stimulate coagulation systemically. SynthoPlate™ significantly improves hemostasis in thrombocytopenic mice dose-dependently.

关键词

bleeding time，hemostasis，platelet transfusion，platelets，thrombocytop
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