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Lens Endogenous Peptide αA66-80 Generates Hydrogen Peroxide and Induces Cell Apoptosis.

Aging Dis. 2017-02; 
RajuMurugesan, SanthoshkumarPuttur, SharmaK Kri
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Peptide Synthesis … manufacturer. The peptides αA66-80 [SDRDKFVIFLDVKHF], proline-substituted αA66-80 (V72P) [SDRDKFPIFLDVKHF] and alanine-substituted αA66-80 (H79A) [SDRDKFPIF LDVKAF] were supplied by GenScript (Piscataway, NJ) … Get A Quote

摘要

In previous studies, we reported the presence of a large number of low-molecular-weight (LMW) peptides in aged and cataract human lens tissues. Among the LMW peptides, a peptide derived from αA-crystallin, αA66-80, was found in higher concentration in aged and cataract lenses. Additional characterization of the αA66-80 peptide showed beta sheet signature, and it formed well-defined unbranched fibrils. Further experimental data showed that αA66-80 peptide binds α-crystallin, impairs its chaperone function, and attracts additional crystallin proteins to the peptide α-crystallin complex, leading to the formation of larger light scattering aggregates. It is well established that Aβ peptide ex... More

关键词

amyloid,cataract,crystallin,hydrogen peroxide,lens,pep
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