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Factor VII Tokushima (Cys22→Gly) is not γ-carboxylated due to a disrupted γ-carboxylase recognition site.

Thromb. Res.. 2017-10; 
DissingChristian, Persson
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Codon Optimization … Constructs for protein expression in Chinese hamster ovary (CHO) cells, encoding PZ, FVII, C17S/C22S-FVII, and C22G-FVII (Genscript, Piscataway, NJ, USA), with a C-terminal HPC4 tag and stop codon, were inserted into a pQMCF5 vector flanked by BsiWI and NheI … Get A Quote

摘要

关键词

Factor VII，Factor VII deficiency，Missense mutation，Protein Z，γ-Carboxyglutamic acid，γ-Carboxylase recognition
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