Salinity is one of the major limiting factors in plant growth and productivity. Cucumis melo L. is a widely cultivated plant， but its productivity is significantly influenced by the level of salinity in soil. Symbiotic colonization of plants with Piriformospora indica has shown a promotion in plants growth and tolerance against biotic stress. In this study， physiological markers such as ion analysis， antioxidant determination， proline content， electrolyte leakage and chlorophyll measurement were assessed in melon cultivar under two concentrations (100 and 200 mM) of NaCl with and without P. indica inoculation. Results showed that the endophytic inoculation consistently upregulated the level of antioxidants， enhanced plants to antagonize salinity stress. The expression level of an RNA editing factor (SLO2) which is known to participate in mitochondria electron transport chain was analyzed， and its full mRNA sequence was obtained by rapid amplification of cDNA ends (RACE). Under salinity stress， the expression level of SLO2 was increased， enhancing the plant's capability to adapt to the stress. However， P. indica inoculation further elevated the expression level of SLO2. These findings suggested that the symbiotic association of fungi could help the plants to tolerate the salinity stress.