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SPX-101 is stable in and retains function after exposure to cystic fibrosis sputum.

J. Cyst. Fibros.. 2018; 
SesmaJuliana I，WuBryant，StuhlmillerTimothy J，ScottDav
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Peptide Synthesis Peptides were manufactured by Genscript (Piscataway, NJ) at N95% purity. The sequences are as follows; SPX-101 (aaLPIPLDQTaa), ABC (aaDILLPPQTaa), S18 (GGLPV PLDQTLPLNVNPA) and 4031 (aaLPIPLDQTAAAV VRGRaa) where “a” implies D-Alanine. Recombinant human SPLUNC1 (BPIFA1) was purchased from LS Bio (Seattle, WA). All other reagents were from Sigma Aldrich (St. Louis, MO) unless otherwise noted. Get A Quote

摘要

In healthy lungs， epithelial sodium channel (ENaC) is regulated by short， palate， lung， and nasal clone 1 (SPLUNC1). In cystic fibrosis (CF)， ENaC is hyperactivated in part due to a loss of SPLUNC1 function. We have developed SPX-101 to replace the lost function of SPLUNC1 in the CF lung.

关键词

Airway hydration，ENaC，Mucus，SPX
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