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Src signaling in a low-complexity unicellular kinome.

Sci Rep. 2018; 
SugaHiroshi,MillerW
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Peptide Synthesis Te cDNAs for Creolimax PTPs CfrPTP-1, CfrPTP-3, CfrPTP-4, CfrPTP-5, and CfrPTP-7 were synthesized by GenScript afer optimizing codons for E. coli expression. Fluorescently labeled pYEEI peptide was synthesized by GeneMed Synthesis, Inc. Get A Quote
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摘要

Creolimax fragrantissima is a member of the ichthyosporean clade, the earliest branching holozoan lineage. The kinome of Creolimax is markedly reduced as compared to those of metazoans. In particular, Creolimax possesses a single non-receptor tyrosine kinase: CfrSrc, the homolog of c-Src kinase. CfrSrc is an active tyrosine kinase, and it is expressed throughout the lifecycle of Creolimax. In animal cells, the regulatory mechanism for Src involves tyrosine phosphorylation at a C-terminal site by Csk kinase. The lack of Csk in Creolimax suggests that a different mode of negative regulation must exist for CfrSrc. We demonstrate that CfrPTP-3, one of the 7 tyrosine-specific phosphatases (PTPs) in Creol... More

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