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Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial.

npj Vaccines. 2018; 
PilletStéphane,AubinÉric,TrépanierSonia,PoulinJean-François,Yassine-DiabBader,Ter MeulenJan,WardBrian J,LandryNath
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Peptide Synthesis Briefly, peripheral blood mononucleated cells (PBMC) were stimulated ex vivo with 2.5 μg/ml of peptide pool consisting of 15mer peptides overlapping by 11 amino acids spanning the complete HA of the homologous A/Indonesia/05/2005 H5N1 (H5) or heterosubtypic A/Japan/305/1957 H2N2 (H2), A/California/07/2009 H1N1 (H1) or A/Hangzhou/1/2013 H7N9 (H7) strains (GenScript, Piscataway, NJ). Get A Quote

摘要

The hemagglutinination inhibition (HI) response remains the gold standard used for the licensure of influenza vaccines. However, cell-mediated immunity (CMI) deserves more attention, especially when evaluating H5N1 influenza vaccines that tend to induce poor HI response. In this study, we measured the humoral response (HI) and CMI (flow cytometry) during a Phase II dose-ranging clinical trial (NCT01991561). Subjects received two intramuscular doses, 21 days apart, of plant-derived virus-like particles (VLP) presenting the A/Indonesia/05/2005 H5N1 influenza hemagglutinin protein (H5) at the surface of the VLP (H5VLP). The vaccine was co-administrated with Alhydrogel or with a glucopyranosyl lipid adjuv... More

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