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Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles.

Front Oncol. 2017;

GrandiAlberto，TomasiMichele，ZanellaIlaria，GanfiniLuisa，CaproniElena，FantappièLaura，IreneCarmela，FrattiniLuca，IsaacSamine J，KönigEnrico，ZerbiniFrancesca，TavariniSimona，SammicheliChiara，GiustiFabiola，FerlenghiIlaria，ParriMatteo，GrandiG

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摘要

Bacterial outer membrane vesicles (OMVs) are naturally produced by all Gram-negative bacteria and， thanks to their plasticity and unique adjuvanticity， are emerging as an attractive vaccine platform. To test the applicability of OMVs in cancer immunotherapy， we decorated them with either one or two protective epitopes present in the B16F10EGFRvIII cell line and tested the protective activity of OMV immunization in C57BL/6 mice challenged with B16F10EGFRvIII.