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Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells.

J Hematol Oncol. 2017;

QinLe，LaiYunxin，ZhaoRuocong，WeiXinru，WengJianyu，LaiPeilong，LiBaiheng，LinSimiao，WangSuna，WuQiting，LiangQiubin，LiYangqiu，ZhangXuchao，WuYilong，LiuPentao，YaoYao，PeiDuanqing，DuXin，Li

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Codon Optimization	The CARs were codon-optimized and chemically synthesized using Genscript.	Get A Quote

摘要

Multiple iterations of chimeric antigen receptors (CARs) have been developed， mainly focusing on intracellular signaling modules. However， the effect of non-signaling extracellular modules on the expansion and therapeutic efficacy of CARs remains largely undefined.