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Dendritic Cell Membrane Vesicles for Activation and Maintenance of Antigen-Specific T Cells.

Adv Healthc Mater. 2019; 
OchylLukasz J,MoonJam
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Peptide Synthesis … SIINFEKL or fluorescently labeled SIINFEK(FITC)L peptides (Genscript) were loaded at 100 µg mL −1 onto DC‐MVs by incubation at 37 °C … 5 × 10 5 cells were adoptively transferred into naïve congenic Thy1.2+ C57BL/6 mice (female, 6–8 weeks, Envigo, USA) via intravenous … Get A Quote

摘要

Cell membranes have recently gained attention as a promising drug delivery system. Here, dendritic cell membrane vesicles (DC-MVs) are examined as a platform to promote T cell responses. Nanosized DC-MVs are derived from DCs pretreated with monophosphoryl lipid A (MPLA), a FDA-approved immunostimulatory adjuvant. These "mature" DC-MVs activate DCs in vitro and increase their expression of costimulatory markers. DC-MVs also promote cross-priming of antigen-specific T cells in vitro, increasing their survival and CD25 expression. In addition, these mature DC-MVs potently augment the expansion of adoptively transferred CD8+ T cells in vivo, generating twofold to fourfold higher frequency of antigen-speci... More

关键词

T cell activation,membrane vesicles,peptide antigens,vacc
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